The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …

Resistance to drug treatment is an important hurdle in the therapy of many brain disorders,
including brain cancer, epilepsy, schizophrenia, depression and infection of the brain with …

ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …

The blood–brain barrier (BBB) serves as a protective mechanism for the brain by preventing
entry of potentially harmful substances from free access to the central nervous system …

Insecticidal crystal toxins derived from the soil bacterium Bacillus thuringiensis (Bt) are
widely used as biopesticide sprays or expressed in transgenic crops to control insect pests …

One of the main difficulties with primary rat brain endothelial cell (RBEC) cultures is
obtaining pure cultures. The variation in purity limits the achievement of in vitro models of the …

The intrinsic or acquired resistance to anticancer drugs remains one of the most significant
factors impeding the progress of cancer chemotherapy. This phenomenon often involves …

Resistance to chemotherapy is a critical issue in the management of breast cancer patients.
The nature of clinical drug resistance is likely to be multifactorial. However, in the last …

Recently, hepatic transport processes have been recognized as important determinants of
drug disposition. Therefore, it is not surprising that characterization of the hepatic transport …

Acute lung injury (ALI) and acute kidney injury (AKI) are major causes of sepsis-induced
mortality. The objective of the study is to evaluate the effect of tocilizumab (TCZ), an IL-6 …