Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

Mass spectrometry–based glycoproteomics has gone through some incredible
developments over the last few years. Technological advances in glycopeptide enrichment …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Glycans are fundamental cellular building blocks, involved in many organismal functions.
Advances in glycomics are elucidating the essential roles of glycans. Still, it remains …

Characterization of highly glycosylated biopharma-ceuticals by mass spectrometry is
challenging because of the huge chemical space of coexistent glycoforms present. Here, we …

Access to defined glycans and glycoconjugates is pivotal for discovery, dissection, and
harnessing of a range of biological functions orchestrated by cellular glycosylation …

Mass spectrometry (MS) plays a key role throughout all stages of drug development and is
now as ubiquitous as other analytical techniques such as surface plasmon resonance …