The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
Liver cancer is a common cancer worldwide. Although the etiological factors of liver
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
carcinogenesis are well defined, the underlying molecular mechanisms remain largely …
Functions of N6-methyladenosine and its role in cancer
L He, H Li, A Wu, Y Peng, G Shu, G Yin - Molecular cancer, 2019 - Springer
Abstract N6-methyladenosine (m6A) is methylation that occurs in the N6-position of
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
adenosine, which is the most prevalent internal modification on eukaryotic mRNA …
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
Y Chen, Y Zhao, J Chen, C Peng, Y Zhang, R Tong… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m 6 A) modification is an emerging layer of
epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular …
epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular …
[HTML][HTML] m6A regulator-based methylation modification patterns characterized by distinct tumor microenvironment immune profiles in colon cancer
W Chong, L Shang, J Liu, Z Fang, F Du, H Wu, Y Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Recent studies have highlighted the biological significance of RNA N 6-methyladenosine (m
6 A) modification in tumorigenicity and progression. However, it remains unclear whether m …
6 A) modification in tumorigenicity and progression. However, it remains unclear whether m …
Mechanism of RNA modification N6-methyladenosine in human cancer
Z Zhou, J Lv, H Yu, J Han, X Yang, D Feng, Q Wu… - Molecular cancer, 2020 - Springer
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA
modifications has gained increasing interest in the scientific community. The discovery of N6 …
modifications has gained increasing interest in the scientific community. The discovery of N6 …
Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer
Y Chen, Y Lin, Y Shu, J He, W Gao - Molecular cancer, 2020 - Springer
As a critical internal RNA modification in higher eukaryotes, N 6-methyladenosine (m 6 A)
has become the hotspot of epigenetics research in recent years. Extensive studies on …
has become the hotspot of epigenetics research in recent years. Extensive studies on …
Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma
Y Li, J Gu, F Xu, Q Zhu, Y Chen, D Ge… - Briefings in …, 2021 - academic.oup.com
Abstract N6-methyladenosine (m6A) modification can regulate a variety of biological
processes. However, the implications of m6A modification in lung adenocarcinoma (LUAD) …
processes. However, the implications of m6A modification in lung adenocarcinoma (LUAD) …
Epigenetic regulation of m6A modifications in human cancer
W Zhao, X Qi, L Liu, S Ma, J Liu, J Wu - Molecular Therapy-Nucleic Acids, 2020 - cell.com
N6-methyladenosine (m 6 A) is the most prevalent internal RNA modification, especially
within eukaryotic messenger RNAs (mRNAs). m 6 A modifications of RNA regulate splicing …
within eukaryotic messenger RNAs (mRNAs). m 6 A modifications of RNA regulate splicing …
The role of N6-methyladenosine mRNA in the tumor microenvironment
M Li, X Zha, S Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
In recent years, the most widely distributed eukaryotic messenger RNA (mRNA)
modification, N6-methyladenosine (m6A), has received a large amount of interest, in part …
modification, N6-methyladenosine (m6A), has received a large amount of interest, in part …
Metabolic reprogramming driven by IGF2BP3 promotes acquired resistance to EGFR inhibitors in non–small cell lung cancer
Z Lin, J Li, J Zhang, W Feng, J Lu, X Ma, W Ding… - Cancer …, 2023 - aacrjournals.org
Acquired resistance represents a bottleneck for effective molecular targeted therapy in lung
cancer. Metabolic adaptation is a distinct hallmark of human lung cancer that might …
cancer. Metabolic adaptation is a distinct hallmark of human lung cancer that might …