Pathophysiology of atherosclerosis

S Jebari-Benslaiman, U Galicia-García… - International journal of …, 2022 - mdpi.com
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading
cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and …

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Programmed cell death in atherosclerosis and vascular calcification

M Li, ZW Wang, LJ Fang, SQ Cheng, X Wang… - Cell death & …, 2022 - nature.com
The concept of cell death has been expanded beyond apoptosis and necrosis to additional
forms, including necroptosis, pyroptosis, autophagy, and ferroptosis. These cell death …

Vascular smooth muscle cells in atherosclerosis

GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Vascular calcification—new insights into its mechanism

SJ Lee, IK Lee, JH Jeon - International journal of molecular sciences, 2020 - mdpi.com
Vascular calcification (VC), which is categorized by intimal and medial calcification,
depending on the site (s) involved within the vessel, is closely related to cardiovascular …

Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease

P Lacolley, V Regnault, P Segers… - Physiological …, 2017 - journals.physiology.org
The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation: Involvement of vitamin K-dependent processes

P Petsophonsakul, M Furmanik, R Forsythe… - … , and vascular biology, 2019 - ahajournals.org
Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …

Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics

M **, J Fang, J Wang, X Shao, S Xu, P Liu… - Acta Pharmacologica …, 2023 - nature.com
Atherosclerosis, one of the life-threatening cardiovascular diseases (CVDs), has been
demonstrated to be a chronic inflammatory disease, and inflammatory and immune …

[HTML][HTML] Cellular crosstalk between endothelial and smooth muscle cells in vascular wall remodeling

N Méndez-Barbero, C Gutiérrez-Muñoz… - International journal of …, 2021 - mdpi.com
Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …