ABSTRACT Carbon/nitrogen (C/N) balance sensing is a key requirement for the
maintenance of cellular homeostasis. Therefore, cyanobacteria have evolved a …

Carbon and nitrogen are the two most abundant nutrient elements for all living organisms,
and their metabolism is tightly coupled. What are the signaling mechanisms that cells use to …

Prochlorococcus and Synechococcus are the two most abundant photosynthetic organisms
on Earth, with a strong influence on the biogeochemical carbon and nitrogen cycles. Early …

Yeast two-hybrid approaches, which are based on fusion proteins that must co-localise to
the nucleus to reconstitute the transcriptional activity of GAL4, have greatly contributed to our …

Many microorganisms produce resting cells with very low metabolic activity that allow them
to survive phases of prolonged nutrient or energy stress. In cyanobacteria and some …

The conserved cyanobacterial protein PipX is part of a complex interaction network with
regulators involved in essential processes that include metabolic homeostasis and ribosome …

PipX is a unique cyanobacterial protein identified by its ability to bind to PII and NtcA, two
key regulators involved in the integration of signals of the nitrogen/carbon and energy status …

Transcription factors respond to multilevel stimuli and co-occupy promoter regions of target
genes to activate RNA polymerase (RNAP) in a cooperative manner. To decipher the …

Microbial life in the oceans impacts the entire marine ecosystem, global biogeochemistry
and climate. The marine cyanobacterium Prochlorococcus, an abundant component of this …

Primary production by Prochlorococcus, the smallest known free-living photosynthetic
organism in terms of both physical and genomic size, is thought to have a significant role in …