Non-coding RNAs in human disease
M Esteller - Nature reviews genetics, 2011 - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …
context of the widespread disruption of microRNA (miRNA) expression and function that is …
Chemical modification and design of anti-miRNA oligonucleotides
KA Lennox, MA Behlke - Gene therapy, 2011 - nature.com
Antisense techniques have been employed for over 30 years to suppress expression of
target RNAs. Recently, microRNAs (miRNAs) have emerged as a new class of small, non …
target RNAs. Recently, microRNAs (miRNAs) have emerged as a new class of small, non …
TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
Y Kawahara, A Mieda-Sato - Proceedings of the National …, 2012 - National Acad Sciences
Although aberrant microRNA (miRNA) expression is linked to human diseases including
cancer, the mechanisms that regulate the expression of each individual miRNA remain …
cancer, the mechanisms that regulate the expression of each individual miRNA remain …
Toehold‐initiated rolling circle amplification for visualizing individual microRNAs in situ in single cells
The ability to quantitate and visualize microRNAs (miRNAs) in situ in single cells would
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …
Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of …
The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …
Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
Background Astrocytes regulate neuronal function, synaptic formation and maintenance
partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) …
partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) …
[HTML][HTML] RNA dysregulation in amyotrophic lateral sclerosis
Z Butti, SA Patten - Frontiers in genetics, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …
and is characterized by the degeneration of upper and lower motor neurons. It has become …
miR-9: a versatile regulator of neurogenesis
M Coolen, S Katz, L Bally-Cuif - Frontiers in cellular neuroscience, 2013 - frontiersin.org
Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since
it is one of the most highly expressed microRNAs in the develo** and adult vertebrate …
it is one of the most highly expressed microRNAs in the develo** and adult vertebrate …
[HTML][HTML] Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases
AM Janas, K Sapoń, T Janas, MHB Stowell… - Biochimica et Biophysica …, 2016 - Elsevier
The function of human nervous system is critically dependent on proper interneuronal
communication. Exosomes and other extracellular vesicles are emerging as a novel form of …
communication. Exosomes and other extracellular vesicles are emerging as a novel form of …
The role of extracellular vesicles in neurodegenerative diseases
Extracellular vesicles, including exosomes, are small membranous vesicles released from
many biotypes, contributing to the disease progression and spreading. These extracellular …
many biotypes, contributing to the disease progression and spreading. These extracellular …