Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges

PC Vioglio, MR Chierotti, R Gobetto - Advanced drug delivery reviews, 2017 - Elsevier
In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)

D Tan, L Loots, T Friščić - Chemical Communications, 2016 - pubs.rsc.org
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …

Creating cocrystals: A review of pharmaceutical cocrystal preparation routes and applications

M Karimi-Jafari, L Padrela, GM Walker… - Crystal Growth & …, 2018 - ACS Publications
Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

Mechanochemistry for organic chemists: an update

D Tan, T Friščić - European Journal of Organic Chemistry, 2018 - Wiley Online Library
We provide a brief overview of recent advances in the use of mechanochemical techniques
for the synthesis of organic molecules and materials, highlighting selected examples of …

High power explosive with good sensitivity: a 2: 1 cocrystal of CL-20: HMX

O Bolton, LR Simke, PF Pagoria… - Crystal Growth & …, 2012 - ACS Publications
A novel energetic cocrystal predicted to exhibit greater power and similar sensitivity to that of
the current military standard explosive 1, 3, 5, 7-tetranitro-1, 3, 5, 7-tetrazacyclooctane …

[HTML][HTML] A practical guide to pharmaceutical polymorph screening & selection

EH Lee - Asian Journal of Pharmaceutical Sciences, 2014 - Elsevier
Prevalence and importance of polymorphism occurring in pharmaceutical compounds are
well recognized. It is of great importance to prepare and select the right form from the …

Mechanical stimulation and solid seeding trigger single-crystal-to-single-crystal molecular domino transformations

H Ito, M Muromoto, S Kurenuma, S Ishizaka… - Nature …, 2013 - nature.com
Numerous studies have focused on the mechanical control of solid structures and phase
changes in molecular crystals. However, the molecular-level understanding of how …

Barbituric acids as a useful tool for the construction of coordination and supramolecular compounds

KT Mahmudov, MN Kopylovich, AM Maharramov… - Coordination Chemistry …, 2014 - Elsevier
In spite of its impressive record in medicinal chemistry, the role of barbituric acid H 3 BA
(pyrimidine-2, 4, 6 (1H, 3H, 5H)-trione) in coordination, organometallic and supramolecular …

Recent advances in photofunctional polymorphs of molecular materials

B Lu, S Liu, D Yan - Chinese Chemical Letters, 2019 - Elsevier
Recently, molecule-based luminescent materials have been drawing extensive attention
due to their desirable properties and promising applications in the fields of sensors, lighting …

Quantitative investigations of intermolecular interactions in 2-amino-3-nitropyridine polymorphs: Inputs from quantum mechanical calculations

S Islam, P Dey, P Das, SK Seth - Journal of Molecular Structure, 2023 - Elsevier
Two polymorphic forms (Form–I and Form–II) of 2-amino-3-nitropyridine are structurally
characterized by single crystal X-ray diffraction analysis and compared with another …