Liver cancer is the second leading cause of cancer‐related deaths, and hepatocellular
carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently …

Virtually all metazoan cells contain at least one and usually several types of transmembrane
proteoglycans. These are varied in protein structure and type of polysaccharide, but the total …

Heparan sulfate (HS) is a biopolymer consisting of variably sulfated repeating disaccharide
units. The anticoagulant heparin is a highly sulfated intracellular variant of HS. HS has …

Purpose: GC33 is a novel recombinant fully humanized monoclonal antibody that binds to
human glypican-3 (GPC3). The antitumor activity of GC33 was shown in preclinical models …

Hepatocellular carcinoma (HCC) is the major subtype of liver cancer, which ranks sixth in
cancer incidence and third in mortality. Although great strides have been made in novel …

Heparan sulfate proteoglycans (HSPGs) act as coreceptors or storage sites for growth
factors and cytokines such as fibroblast growth factor and Wnts. Glypican 3 (GPC3) is the …

Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide.
In ninety percent of the cases it develops as a result of chronic liver damage and it is thus a …

Background The sulfation pattern of heparan sulfate chains influences signaling events
mediated by heparan sulfate proteoglycans located on cell surface. SULF1 and SULF2 are …

Ovarian cancer is one of the most lethal malignancies of the female reproductive system.
Platinum-resistance is the major obstacle in the successful treatment of ovarian cancer …

Hepatocellular carcinoma (HCC) is a malignant tumor with a fairly poor prognosis (5-year
survival of less than 50%). Using sorafenib, the only food and drug administration (FDA) …