Selenium is a trace element essential to human health largely because of its incorporation
into selenoproteins that have a wide range of protective functions. Selenium has an ongoing …

Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

It is well known that heterocycles are among the most significant molecules for everyday life,
ranging from natural products and bioactive substances to functional materials. This review …

Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases
(HKs), play crucial roles. Cancer cells are characterized by specific expression levels of …

Incorporation of selenium (Se) atom into small molecules can substantially enhance their
antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral …

Conventional direct C− H selenylation suffers from simple selenation with limited atom
economy and complicated reaction system. In this work, we designed benzoselenazolone …

Ebselen is a synthetic organoselenium radical scavenger compound that possesses
glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols …

Background: Sulfur-containing compounds represent an important class of chemical
compounds due to their wide range of biological and pharmaceutical properties. Moreover …

Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is
an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this …

The worldwide prevalence of NDM-1-producing bacteria has drastically undermined the
clinical efficacy of the last line antibiotic of carbapenems, prompting a need to devise …