Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising
drug target for cancer therapy. A key Mdm2 function is to promote ubiquitylation and …

Microglia are increasingly implicated as a source of non‐neural regulation of postnatal
neurogenesis and neuronal development. To evaluate better the contributions of microglia …

NUMB is a cell fate determinant, which, by asymmetrically partitioning at mitosis, controls
cell fate choices by antagonising the activity of the plasma membrane receptor of the …

We investigated the ability of a new type of biological material, the self-assembling peptide
scaffold, to foster tissue-like function by a putative adult rat hepatocyte progenitor cell line …

Stem cells have been identified and characterized in a variety of tissues. In this review we
examine possible shared properties of stem cells. We suggest that irrespective of their lineal …

Numerous publications have investigated stem‐cell biology and the possible therapeutic
use of stem cells in a wide range of injuries and diseases. This interest has been fuelled by …

At the turn of a decade of intensive wishful thinking,“mesenchymal stem cells” are changing
their profile, while retaining their charm. As hopes to turn bone into brain or vice versa seem …

The protein Numb does not live up to its name. This passive-sounding protein is anything
but spent. Originally identified as a cell-fate determinant in Drosophila development, Numb …

Once mutated, a single cell must expand into a clone before becoming significant for
carcinogenesis. The forces driving clonal expansion and the obstacles that must be …