Next generation of immune checkpoint inhibitors and beyond
The immune system is the core defense against cancer development and progression.
Failure of the immune system to recognize and eliminate malignant cells plays an important …
Failure of the immune system to recognize and eliminate malignant cells plays an important …
NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
Cytokines and chemokines involved in osteoarthritis pathogenesis
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …
Kinase inhibition in autoimmunity and inflammation
AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
The IL-1 family of cytokines and receptors in rheumatic diseases
CA Dinarello - Nature Reviews Rheumatology, 2019 - nature.com
More than any other cytokine family, the 11 members of the IL-1 family are associated with
innate immune responses, which occur in acute inflammation and chronic inflammatory …
innate immune responses, which occur in acute inflammation and chronic inflammatory …
Interleukin-1 beta—a friend or foe in malignancies?
R Bent, L Moll, S Grabbe, M Bros - International journal of molecular …, 2018 - mdpi.com
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …
Single-cell RNA sequencing of tumor-infiltrating NK cells reveals that inhibition of transcription factor HIF-1α unleashes NK cell activity
Enhancing immune cell functions in tumors remains a major challenge in cancer
immunotherapy. Hypoxia is a common feature of solid tumors, and cells adapt by …
immunotherapy. Hypoxia is a common feature of solid tumors, and cells adapt by …
Interleukin-1β signaling in osteoarthritis–chondrocytes in focus
Z Jenei-Lanzl, A Meurer, F Zaucke - Cellular Signalling, 2019 - Elsevier
Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that
affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In …
affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In …
Toll‐like receptors: general molecular and structural biology
Background/Aim. Toll‐like receptors (TLRs) are pivotal biomolecules in the immune system.
Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune …
Today, we are all aware of the importance of TLRs in bridging innate and adaptive immune …
Structural basis of IL-1 family cytokine signaling
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …