The properties of the cell types that are selectively vulnerable in Huntington's disease (HD)
cortex, the nature of somatic CAG expansions of mHTT in these cells, and their importance …

Degeneration of neurons and circuits across the striatum shows stereotyped time-course
and spatial topography patterns that are distinct for Huntington's disease, Parkinson's …

Neurotrophins and their receptors are distinctly expressed during brain development and
play crucial roles in the formation, survival, and function of neurons in the nervous system …

Deciphering the striatal interneuron diversity is key to understanding the basal ganglia
circuit and to untangling the complex neurological and psychiatric diseases affecting this …

Brain subcortical structures are paramount in many cognitive functions and their aberrations
during infancy are predisposed to various neurodevelopmental and neuropsychiatric …

The mammalian telencephalon contains distinct GABAergic projection neuron and
interneuron types, originating in the germinal zone of the embryonic basal ganglia. How …

Long-range glutamatergic inputs originating from the cortex and thalamus are indispensable
for striatal development, providing the foundation for motor and cognitive functions. Despite …

The balance between cell proliferation and differentiation is essential for maintaining the
neural progenitor pool and brain development. Although the mechanisms underlying cell …

Neuronal DNA modifications differ from those in other cells, including methylation outside
CpG context and abundant 5-hydroxymethylation whose relevance for neuronal identities …

In addition to neuronal migration, brain development, and adult plasticity, the extracellular
matrix protein Reelin has been extensively implicated in human psychiatric disorders such …