Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives
Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimising the use of
biologics, and in particular anti-tumour necrosis factor (anti-TNF) therapy, in inflammatory …
biologics, and in particular anti-tumour necrosis factor (anti-TNF) therapy, in inflammatory …
Artificial intelligence and machine learning approaches to facilitate therapeutic drug management and model-informed precision dosing
Background: Therapeutic drug monitoring (TDM) and model-informed precision dosing
(MIPD) have greatly benefitted from computational and mathematical advances over the …
(MIPD) have greatly benefitted from computational and mathematical advances over the …
Antibodies‐to‐infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease
Background Antibodies to infliximab (ATI) are associated with secondary loss of response
and increased risk for drug reactions. Limited studies have associated ATI with increased …
and increased risk for drug reactions. Limited studies have associated ATI with increased …
Precision dosing of anti-TNF therapy in pediatric inflammatory bowel disease
A Samuels, KG Whaley, P Minar - Current gastroenterology reports, 2023 - Springer
Abstract Purpose of the Review This review focuses on recent advancements in anti-TNF
therapeutic drug monitoring (TDM), pharmacogenetics and personalized drug selection for …
therapeutic drug monitoring (TDM), pharmacogenetics and personalized drug selection for …
Failure to achieve target drug concentrations during induction and not HLA-DQA1∗ 05 carriage is associated with antidrug antibody formation in patients with …
EA Spencer, J Stachelski, T Dervieux… - …, 2022 - gastrojournal.org
In 2020 the PANTS (Personalising Anti-TNF Therapy in Crohn's Disease) study reported an
association between HLADQA1* 05 and the development of antidrug antibodies (ADAs) to …
association between HLADQA1* 05 and the development of antidrug antibodies (ADAs) to …
A model-based tool for guiding infliximab induction dosing to maximize long-term deep remission in children with inflammatory bowel diseases
Abstract Background and Aims Adequate infliximab concentrations during induction
treatment are predictive for deep remission [corticosteroid-free clinical and endoscopic …
treatment are predictive for deep remission [corticosteroid-free clinical and endoscopic …
Multicenter cohort study of infliximab pharmacokinetics and therapy response in pediatric acute severe ulcerative colitis
KG Whaley, Y **ong, R Karns, JS Hyams… - Clinical …, 2023 - Elsevier
Background & aims We aimed to model infliximab (IFX) pharmacokinetics (PK) in pediatric
acute severe ulcerative colitis (ASUC) and assess the association between PK parameters …
acute severe ulcerative colitis (ASUC) and assess the association between PK parameters …
Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT
Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal posttransplant
complication of hematopoietic stem cell transplantation. We recently reported that survival …
complication of hematopoietic stem cell transplantation. We recently reported that survival …
Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of …
Background Vedolizumab for inflammatory bowel disease (IBD) is often intensified based on
distinct pharmacokinetics in children. Prior adult‐specific population pharmacokinetic …
distinct pharmacokinetics in children. Prior adult‐specific population pharmacokinetic …
Tutorial on model selection and validation of model input into precision dosing software for model‐informed precision dosing
ZL Taylor, EA Poweleit, K Paice… - CPT …, 2023 - Wiley Online Library
There has been rising interest in using model‐informed precision dosing to provide
personalized medicine to patients at the bedside. This methodology utilizes population …
personalized medicine to patients at the bedside. This methodology utilizes population …