[HTML][HTML] Multiphasic scaffolds for the repair of osteochondral defects: outcomes of preclinical studies

R Chen, JS Pye, J Li, CB Little, JJ Li - Bioactive Materials, 2023 - Elsevier
Osteochondral defects are caused by injury to both the articular cartilage and subchondral
bone within skeletal joints. They can lead to irreversible joint damage and increase the risk …

Clinical application status of articular cartilage regeneration techniques: tissue‐engineered cartilage brings new hope

S Jiang, W Guo, G Tian, X Luo, L Peng… - Stem Cells …, 2020 - Wiley Online Library
Hyaline articular cartilage lacks blood vessels, lymphatics, and nerves and is characterised
by limited self‐repair ability following injury. Traditional techniques of articular cartilage …

[HTML][HTML] Progress and prospect of technical and regulatory challenges on tissue-engineered cartilage as therapeutic combination product

X Guo, Y Ma, Y Min, J Sun, X Shi, G Gao, L Sun… - Bioactive Materials, 2023 - Elsevier
Hyaline cartilage plays a critical role in maintaining joint function and pain. However, the
lack of blood supply, nerves, and lymphatic vessels greatly limited the self-repair and …

Regeneration of articular cartilage defects: Therapeutic strategies and perspectives

X Guo, L **, M Yu, Z Fan, W Wang… - Journal of Tissue …, 2023 - journals.sagepub.com
Articular cartilage (AC), a bone-to-bone protective device made of up to 80% water and
populated by only one cell type (ie chondrocyte), has limited capacity for regeneration and …

Consensus guidelines on interventional therapies for knee pain (STEP Guidelines) from the American Society of Pain and Neuroscience

CW Hunter, TR Deer, MR Jones… - Journal of pain …, 2022 - Taylor & Francis
Knee pain is second only to the back as the most commonly reported area of pain in the
human body. With an overall prevalence of 46.2%, its impact on disability, lost productivity …

Operative management of osteochondral lesions of the talus: 2024 recommendations of the working group 'clinical tissue regeneration'of the German Society of …

M Walther, O Gottschalk, M Aurich - EFORT Open Reviews, 2024 - eor.bioscientifica.com
The working group 'Clinical Tissue Regeneration'of the German Society of Orthopedics and
Traumatology (DGOU) issues this paper with updating its guidelines. Literature was …

Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair

RM Stefani, AJ Lee, AR Tan, SS Halder, Y Hu, XE Guo… - Acta biomaterialia, 2020 - Elsevier
Articular cartilage defects are a common source of joint pain and dysfunction. We
hypothesized that sustained low-dose dexamethasone (DEX) delivery via an acellular …

Cell therapy for cartilage repair

CH Hulme, J Perry, HS McCarthy… - Emerging topics in …, 2021 - portlandpress.com
Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of
tissues and organs, offers great hope for the future of medicine. Cell therapy for treating …

Donor‐site morbidity after osteochondral autologous transplantation for osteochondritis dissecans of the capitellum: a systematic review and meta‐analysis

R Bexkens, PT Ogink, JN Doornberg… - Knee Surgery …, 2017 - Wiley Online Library
Purpose To determine the rate of donor‐site morbidity after osteochondral autologous
transplantation (OATS) for capitellar osteochondritis dissecans. Methods A literature search …

Formation of osteochondral organoids from murine induced pluripotent stem cells

SK O'Connor, DB Katz, SJ Oswald… - … Engineering Part A, 2021 - liebertpub.com
Osteoarthritis is a debilitating joint disease that is characterized by pathologic changes in
both cartilage and bone, potentially involving cross talk between these tissues that is …