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Chemical immunology: Recent advances in tool development and applications
Immunology was one of the first biological fields to embrace chemical approaches. The
development of new chemical approaches and techniques has provided immunologists with …
development of new chemical approaches and techniques has provided immunologists with …
Accelerating CAR-T Cell Therapies with Small-Molecule Inhibitors
K Mestermann, A Garitano-Trojaola, M Hudecek - BioDrugs, 2024 - Springer
Chimeric antigen receptor T-cell therapies have markedly improved the survival rates of
patients with B-cell malignancies. However, their efficacy in other hematological cancers …
patients with B-cell malignancies. However, their efficacy in other hematological cancers …
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models
Tumor resistance to chimeric antigen receptor T cell (CAR-T) and, in general, to adoptive
cell immunotherapies (ACTs) is a major challenge in the clinic. We hypothesized that …
cell immunotherapies (ACTs) is a major challenge in the clinic. We hypothesized that …
Degradation of IKAROS prevents epigenetic progression of T cell exhaustion in a novel antigen-specific assay
In cancer, chronic antigen stimulation drives effector T cells to exhaustion, limiting the
efficacy of T cell therapies. Recent studies have demonstrated that epigenetic rewiring …
efficacy of T cell therapies. Recent studies have demonstrated that epigenetic rewiring …
Tumor Infiltrating Lymphocytes, CAR-, and T Cell Receptor-Modified T Cells in Solid Cancer Oncology
H Echchannaoui, KJ Legscha, M Theobald - Oncology Research and … - karger.com
Background: Adoptive cellular therapy (ACT) is a promising treatment approach aiming at
enhancing T cell antitumor immune response. ACT includes tumor-infiltrating lymphocytes …
enhancing T cell antitumor immune response. ACT includes tumor-infiltrating lymphocytes …
Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay
In cancer, chronic antigen stimulation drives effector T cells to exhaustion, limiting the
efficacy of T cell therapies. Recent studies have demonstrated that epigenetic rewiring …
efficacy of T cell therapies. Recent studies have demonstrated that epigenetic rewiring …