Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …

Muscular dystrophies are a heterogeneous group of genetic muscle-wasting disorders that
are subdivided based on the region of the body impacted by muscle weakness as well as …

Sarcoglycanopathies are the most severe forms of autosomal recessive limb-girdle muscular
dystrophies (LGMDs), constituting about 10–25% of LGMDs. The clinical phenotype is …

Myofibre necrosis is a central pathogenic process in muscular dystrophies (MD). As post-
lesional regeneration cannot fully compensate for chronic myofibre loss, interstitial tissue …

Skeletal muscle disease severity can often progress asymmetrically across muscle groups
and heterogeneously within tissues. An example is Duchenne Muscular Dystrophy (DMD) in …

Sarcoglycanopathies are heterogeneous proximo-distal diseases presenting severe muscle
alterations. Although there are 6 different sarcoglycan isoforms, sarcoglycanopathies are …

Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in
response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative …

Skeletal muscle (SkM) comprises slow and fast-twitch fibers, which differ in molecular
composition, function, and systemic energy consumption. In addition, muscular dystrophies …

Background Limb-girdle muscular dystrophies constitute a heterogeneous group of
neuromuscular diseases, both clinically and genetically. Limb-girdle muscular dystrophy by …

Sarcoglycanopathies are heterogeneous proximo-distal diseases presenting severe muscle
alterations. These diseases are caused by mutations in genes coding for one of the four …