Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

Promoting remyelination to prevent/reduce neurodegeneration in patients with multiple
sclerosis (MS) is a major therapeutic goal. The longstanding view that the block of …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Remyelination is a neuroprotective regenerative response to demyelination that restores
saltatory conduction and decreases the vulnerability of axons to irreversible degeneration. It …

The pathology in neurodegenerative diseases is often accompanied by inflammation. It is
well-known that many cells within the central nervous system (CNS) also contribute to …

The Sox2 transcription factor, encoded by a gene conserved in animal evolution, has
become widely known because of its functional relevance for stem cells. In the develo** …

Oligodendrocytes provide metabolic and functional support to neuronal cells, rendering
them key players in the functioning of the central nervous system. Oligodendrocytes need to …

Extracellular vesicles (EVs) are heterogeneous cell-derived membranous structures that
arise from the endosome system or directly detach from the plasma membrane. In recent …

Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous
system (CNS) injuries and diseases. However, the roles of these cells and the molecular …