A balance between Six2-dependent self-renewal and canonical Wnt signaling-directed
commitment regulates mammalian nephrogenesis. Intersectional studies using chromatin …

The leading cause of end-stage renal disease in children is attributed to congenital
anomalies of the kidney and urinary tract (CAKUT). Familial clustering and mouse models …

With regard to human induced pluripotent stem cells (hiPSCs), in which adult cells are
reprogrammed into embryonic-like cells using defined factors, their functional and …

Signaling by GDNF through the Ret receptor tyrosine kinase is required for the normal
growth and morphogenesis of the ureteric bud (UB) during kidney development. Recent …

In the kidney, hypoxia contributes to tubulointerstitial fibrosis, but little is known about its
implications for glomerular damage and glomerulosclerosis. Chronic hypoxia was …

Animal development progresses through the stepwise deployment of gene regulatory
networks (GRN) encoded in the genome. Comparative analyses in different species and …

The distal parts of the renal tubule play a critical role in maintaining homeostasis of
extracellular fluids. In this review, we present an in-depth analysis of microarray-based gene …

The uterus is a remarkable organ that must guard against infections while maintaining the
ability to support growth of a fetus without rejection. The Hoxa10 and Hoxa11 genes have …

Background Cisplatin is an effective chemotherapeutic agent. However, acute kidney injury
(AKI) and subsequent kidney function decline limits its use. Dipeptidyl peptidase-4 (DPP-4) …

Background The exocrine pancreas is composed of a branched network of ducts connected
to acini. They are lined by a monolayered epithelium that derives from the endoderm and is …