Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

M Vallet-Regí, F Schüth, D Lozano, M Colilla… - Chemical Society …, 2022 - pubs.rsc.org
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …

Recent progress in the applications of silica-based nanoparticles

AA Nayl, AI Abd-Elhamid, AA Aly, S Bräse - RSC advances, 2022 - pubs.rsc.org
Functionalized silica nanoparticles (SiO2 NPs) have attracted great attention due to their
promising distinctive, versatile, and privileged physiochemical characteristics. These …

[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges

M Behr, J Zhou, B Xu, H Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

L Chen, S Zhang, Y Duan, X Song, M Chang… - Chemical Society …, 2024 - pubs.rsc.org
The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP

Y Lin, E Wagner, U Lächelt - Biomaterials Science, 2022 - pubs.rsc.org
Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications

AR Sharma, YH Lee, A Bat-Ulzii… - Journal of …, 2022 - Springer
Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …

Polymeric micellar nanoparticles for effective CRISPR/Cas9 genome editing in cancer

Y Li, C Li, J Yan, Y Liao, C Qin, L Wang, Y Huang… - Biomaterials, 2024 - Elsevier
The clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9
(Cas9) gene editing has attracted extensive attentions in various fields, however, its clinical …

Carrier strategies boost the application of CRISPR/Cas system in gene therapy

Z Xu, Q Wang, H Zhong, Y Jiang, X Shi, B Yuan… - …, 2022 - Wiley Online Library
Emerging clustered regularly interspaced short palindromic repeat/associated protein
(CRISPR/Cas) genome editing technology shows great potential in gene therapy. However …

[HTML][HTML] An update on mesoporous silica nanoparticle applications in nanomedicine

E Rastegari, YJ Hsiao, WY Lai, YH Lai, TC Yang… - Pharmaceutics, 2021 - mdpi.com
The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential
for meaningful therapeutic benefits. The field of nanomedicine shows promising implications …