Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Inflammation is an essential immune response for the maintenance of tissue homeostasis. In
a general sense, acute and chronic inflammation are different types of adaptive response …

Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily
increasing globally and seems to parallel the increasing prevalence of obesity. It consists of …

As the immune-competent cells of the brain, microglia play an increasingly important role in
maintaining normal brain function. They invade the brain early in development, transform …

Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Numerous studies of rodents suggest that the gut microbiota populations are sensitive to
genetic and environmental influences, and can produce or influence afferent signals that …

Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity
leads to leptin resistance, exacerbating overeating. We reviewed the literature on the …

La obesidad es una enfermedad crónica de origen multifactorial, asociada a
complicaciones de salud potencialmente graves, y con una elevada prevalencia a nivel …