The incidence of the metabolic syndrome has taken epidemic proportions in the past
decades, contributing to an increased risk of cardiovascular disease and diabetes. The …

Bile acids are increasingly being appreciated as complex metabolic integrators and
signalling factors and not just as lipid solubilizers and simple regulators of bile-acid …

Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other
receptor systems, in the appreciation that ligands may exert very diverse pharmacology …

Transcriptional control of cellular energy metabolic pathways is achieved by the coordinated
action of numerous transcription factors and associated coregulators. Several members of …

Steroid hormones regulate essential physiological processes and inadequate levels are
associated with various pathological conditions. Consequently, the process of steroid …

Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that
regulate development, reproduction, and metabolism of lipids, drugs and energy. The …

Hepatic gluconeogenesis is a major pathway that maintains normal plasma glucose levels
during prolonged starvation. The aim of this review is to provide insights into the integration …

Half of the members of the nuclear receptors superfamily are so-called “orphan” receptors
because the identity of their ligand, if any, is unknown. Because of their important biological …

The nuclear orphan receptors for which endogenous ligands have not been identified
include nuclear receptor (NR) 0B1 (adrenal hypoplasia congenita critical region on …

The orphan nuclear receptor SHP (small heterodimer partner) is a transcriptional
corepressor that regulates hepatic metabolic pathways. Here we identified a role for SHP as …