T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

[HTML][HTML] SARS-CoV-2 Omicron variant: recent progress and future perspectives

Y Fan, X Li, L Zhang, S Wan, L Zhang… - Signal transduction and …, 2022 - nature.com
Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been
a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of …

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

Dictionary learning for integrative, multimodal and scalable single-cell analysis

Y Hao, T Stuart, MH Kowalski, S Choudhary… - Nature …, 2024 - nature.com
Map** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …

[HTML][HTML] Systems vaccinology of the BNT162b2 mRNA vaccine in humans

PS Arunachalam, MKD Scott, T Hagan, C Li, Y Feng… - Nature, 2021 - nature.com
The emergency use authorization of two mRNA vaccines in less than a year from the
emergence of SARS-CoV-2 represents a landmark in vaccinology,. Yet, how mRNA …

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID

MC Woodruff, KS Bonham, FA Anam, TA Walker… - Nature …, 2023 - nature.com
While immunologic correlates of COVID-19 have been widely reported, their associations
with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of …

Single-cell multi-omics analysis of the immune response in COVID-19

E Stephenson, G Reynolds, RA Botting… - Nature medicine, 2021 - nature.com
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

Host-directed immunotherapy of viral and bacterial infections: past, present and future

RS Wallis, A O'Garra, A Sher, A Wack - Nature Reviews Immunology, 2023 - nature.com
The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …

A Python library for probabilistic analysis of single-cell omics data

A Gayoso, R Lopez, G **ng, P Boyeau… - Nature …, 2022 - nature.com
To the Editor—Methods for analyzing single-cell data 1–4 perform a core set of
computational tasks. These tasks include dimensionality reduction, cell clustering, cell-state …

[HTML][HTML] Adaptive immunity to SARS-CoV-2 and COVID-19

A Sette, S Crotty - Cell, 2021 - cell.com
The adaptive immune system is important for control of most viral infections. The three
fundamental components of the adaptive immune system are B cells (the source of …