There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative
stress in the pathogenesis of many of the major neurodegenerative and neuroinflammatory …

Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …

In schizophrenia, a developmental redox dysregulation constitutes one 'hub'on which
converge genetic impairments of glutathione synthesis and environmental vulnerability …

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in
endogenous protective mechanisms activated as a result of stimulation of inflammatory …

Several neuropsychiatric diseases are related with stress (posttraumatic stress disorder,
major depressive disorder, anxiety disorders, schizophrenia) and stress exposure modifies …

Agonists of the peroxisome proliferator-activated receptor-γ (PPAR-γ) exert protective effects
in several models of ischemia/reperfusion injury, but their role in stroke is less clear. The …

BACKGROUND: Stressful challenges are associated with variations in immune parameters,
including increased innate immunity/inflammation. Among possible mechanisms through …

Background: Schizophrenia is a chronic syndrome of unknown etiology, predominantly
defined by signs of psychosis. The onset of the disorder occurs typically in late adolescence …

Stress is triggered by numerous unexpected environmental, social or pathological stimuli
occurring during the life of animals, including humans, which determine changes in all of …

Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type
(PPAR-γ) receptors and are used clinically for the treatment of type 2 diabetes where they …