The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary …

The nucleolus represents a highly multifunctional intranuclear organelle in which, in addition
to the canonical ribosome assembly, numerous processes such as transcription, DNA repair …

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of
two ligands joined by a linker, enabling them to simultaneously bind with an E3 ligase and a …

The rates of ribosome production by a nucleolus and of protein biosynthesis by ribosomes
are tightly correlated with the rate of cell growth and proliferation. All these processes must …

Discovered in 1973, nucleolin is one of the most abundant phosphoproteins of the
nucleolus. The ability of nucleolin to be involved in many cellular processes is probably …

Long non-coding RNAs (lncRNAs), which are extensively transcribed from the genome,
have been proposed to be key regulators of diverse biological processes. However, little is …

Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of
surface receptors through which they regulate a broad spectrum of biological processes …

The nucleolus has long been perceived as the site for ribosome biogenesis, but numerous
studies suggest that the nucleolus carefully sequesters crucial proteins involved in multiple …

p53 is possibly the most important mammalian tumor suppressor and it is mutated or lost in
more than half of all human cancers. The stability of p53 is primarily determined by the RING …

Mitochondria are intracellular organelles that are instrumental in the creation of energy,
metabolism, apoptosis, and intrinsic immunity. Mitochondria exhibit an extraordinarily high …