Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …
showed a variety of pharmacological properties, and its derivatives propose a high degree …
Sulfonamide derivatives as multi-target agents for complex diseases
Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives
We have synthesized a series of benzimidazole bearing thiazolidinone derivatives (1-20),
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
Benzenesulfonamide derivatives as potent acetylcholinesterase, α-glycosidase, and glutathione S-transferase inhibitors: biological evaluation and molecular docking …
Sulfonamide derivatives exhibit a wide biological activity and can function as potential
medical molecules in the development of a drug. Studies have reported that the compounds …
medical molecules in the development of a drug. Studies have reported that the compounds …
Discovery of imidazopyridine derived oxadiazole-based thiourea derivatives as potential anti-diabetic agents: Synthesis, in vitro antioxidant screening and in silico …
A series of new imidazopyridine based oxadiazole derivatives (5a-l) were designed and
synthesized. Their structures were confirmed by spectral data and then subjected to in vitro …
synthesized. Their structures were confirmed by spectral data and then subjected to in vitro …
Molecular docking and investigation of 4-(benzylideneamino)-and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors
The discovery of acetylcholinesterase inhibitors is important for the treatment of Alzheimer's
disease (AD), known as the most common type of dementia. Due to the side effects of …
disease (AD), known as the most common type of dementia. Due to the side effects of …
Cross-Electrophile Coupling of Benzyl Halides and Disulfides Catalyzed by Iron
Cross-electrophile couplings are influential reactions that typically require a terminal
reductant or photoredox conditions. We discovered an iron-catalyzed reaction that couples …
reductant or photoredox conditions. We discovered an iron-catalyzed reaction that couples …
Combined QSAR, molecular docking and molecular dynamics study on new Acetylcholinesterase and Butyrylcholinesterase inhibitors
Background and purpose This work deals with several molecular modeling methods used to
discover new therapeutic agents for treating the Alzheimer's disease (AD). The cholinergic …
discover new therapeutic agents for treating the Alzheimer's disease (AD). The cholinergic …
[HTML][HTML] Experimental and computational pharmacological approaches decoding the anti-diabetic molecular mechanism of indole based triazole bearing …
In search for a potent anti-Diabetes therapeutic agent, we have synthesized a series of
indole based triazole derived sulfonothioate derivatives (1–15). These compounds were …
indole based triazole derived sulfonothioate derivatives (1–15). These compounds were …