Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

PI3K/AKT/mTOR dysregulation and reprogramming metabolic pathways in renal cancer: Crosstalk with the VHL/HIF axis

SC Badoiu, M Greabu, D Miricescu… - International journal of …, 2023 - mdpi.com
Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …

PI3K inhibitors in thrombosis and cardiovascular disease

TN Durrant, I Hers - Clinical and Translational Medicine, 2020 - Springer
Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important
intracellular signalling and vesicle trafficking events via the generation of 3 …

Targeting class I-II-III PI3Ks in cancer therapy: Recent advances in tumor biology and preclinical research

B Thibault, F Ramos-Delgado, J Guillermet-Guibert - Cancers, 2023 - mdpi.com
Simple Summary The PI3K/AKT pathway is one of the most important signaling nodes in
cancer. While class I PI3K roles in cancer are well known, class II and III functions in …

Current state and future challenges for PI3K inhibitors in cancer therapy

M Sirico, A D'Angelo, C Gianni, C Casadei, F Merloni… - Cancers, 2023 - mdpi.com
Simple Summary Phosphatidylinositol 3-kinase (PI3K) is a key regulator of many cellular
processes and its hyperactivation promotes tumor cell growth and survival. A broad …

TLR7/8 signalling affects X-sperm motility via the GSK3 α/β-hexokinase pathway for the efficient production of sexed dairy goat embryos

F Ren, H **, Y Ren, Y Li, F Wen, M **an, M Zhao… - Journal of animal …, 2021 - Springer
Background Goat milk is very similar to human milk in terms of its abundant nutrients and
ease of digestion. To derive greater economic benefit, farmers require more female offspring …

N-acylhydrazone derivative modulates cell cycle regulators promoting mitosis arrest and apoptosis in estrogen positive MCF-7 breast cancer cells

ML Melo, R Fonseca, F Pauli, B Zavan… - Toxicology in Vitro, 2023 - Elsevier
Breast cancer is the leading cause of cancer death among women worldwide. About 75% of
all diagnosed cases are hormone-positive, which are treated with hormone therapy …

CircAMOTL1 promotes tumorigenesis through miR-526b/SIK2 axis in cervical cancer

Z Sun, S Niu, F Xu, W Zhao, R Ma… - Frontiers in cell and …, 2020 - frontiersin.org
Background Cervical cancer is one of the most common malignancies in women, leading to
major health problems for its high morbidity and mortality. Numerous studies have …

The role of phosphatidylinositol 3-kinase catalytic subunit type 3 in the pathogenesis of human cancer

CA Chu, YW Wang, YL Chen, HW Chen… - International journal of …, 2021 - mdpi.com
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), the mammalian ortholog of
yeast vesicular protein sorting 34 (Vps34), belongs to the phosphoinositide 3-kinase (PI3K) …

Linking phosphoinositide function to mitosis

L Prever, G Squillero, E Hirsch, F Gulluni - Cell Reports, 2024 - cell.com
Phosphoinositides (PtdIns) are a family of differentially phosphorylated lipid second
messengers localized to the cytoplasmic leaflet of both plasma and intracellular membranes …