Upon stress challenges, proteins/RNAs undergo liquid–liquid phase separation (LLPS) to
fine-tune cell physiology and metabolism to help cells adapt to adverse environments. The …

Single-celled organisms must adapt their physiology to persist and propagate across a wide
range of environmental conditions. The growth and division of bacterial cells depend on …

To further increase the production efficiency of microbial shikimate, a valuable compound
widely used in the pharmaceutical and chemical industries, ten key target genes contributing …

Response regulators function as the output components of two-component systems, which
couple the sensing of environmental stimuli to adaptive responses. Response regulators …

Two-component signal transduction systems (TCSs) are widely conserved in bacteria to
respond to and adapt to the changing environment. Since TCSs are also involved in …

Glutarate is a key monomer in polyester and polyamide production. The low efficiency of the
current biosynthetic pathways hampers its production by microbial cell factories. Herein …

Two-component regulatory systems represent the major paradigm for signal transduction in
prokaryotes. The simplest systems are composed of a sensor kinase and a response …

Bacteria survive and respond to diverse environmental conditions and during infection
inside the host by systematic regulation of stress response genes. E. coli and S …

Spider silk proteins (spidroins) are a remarkable class of biomaterials that exhibit a unique
combination of high-value attributes and can be processed into numerous morphologies for …

After uptake by epithelial cells or engulfment by macrophages, Salmonella resides in an
acidic vacuole. Salmonella senses this acidic compartment through the action of the …