The role of macrophages in cancer development and therapy

E Cendrowicz, Z Sas, E Bremer, TP Rygiel - Cancers, 2021 - mdpi.com
Simple Summary Tumor-Associated Macrophages (TAMs) play an important role in the
development of tumors, modulation of neoangiogenesis, immune suppression, and …

Anti-tumor strategies by harnessing the phagocytosis of macrophages

SY Li, YL Guo, JW Tian, HJ Zhang, RF Li, P Gong… - Cancers, 2023 - mdpi.com
Simple Summary Macrophages are the “big eaters” of the immune system who are in charge
of engulfing undesirable substances. Macrophages are vital for the human body as they are …

Nano‐LYTACs for degradation of membrane proteins and inhibition of CD24/Siglec‐10 signaling pathway

K Wang, A Yu, K Liu, C Feng, Y Hou, J Chen… - Advanced …, 2023 - Wiley Online Library
Lysosome‐targeting chimeras (LYTACs) are an emerging therapeutic modality that
effectively degrade cancer cell membranes and extracellular target proteins. In this study, a …

CD24 is a novel target of chimeric antigen receptor T cells for the treatment of triple negative breast cancer

P Yang, F Yu, Z Yao, X Ding, H Xu, J Zhang - Cancer Immunology …, 2023 - Springer
Triple negative breast cancer (TNBC) is a subtype of breast cancer with the highest degree
of malignancy and the worst prognosis. The application of immunotherapy for TNBC is …

The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target

L Baboci, S Capolla, F Di Cintio, F Colombo… - Journal of …, 2020 - Wiley Online Library
The development of nanostructures for therapeutic purpose is rapidly growing, following the
results obtained in vivo in animal models and in the clinical trials. Unfortunately, the potential …

CD24 blockade as a novel strategy for cancer treatment

Y Wang, H Yu, M Yu, H Liu, B Zhang, Y Wang… - International …, 2023 - Elsevier
The CD24 protein is a heat-stable protein with a small core that undergoes extensive
glycosylation. It is expressed on the surface of various normal cells, including lymphocytes …

Anti-CD24 antibody–nitric oxide conjugate selectively and potently suppresses hepatic carcinoma

F Sun, Y Wang, X Luo, Z Ma, Y Xu, X Zhang, T Lv… - Cancer …, 2019 - aacrjournals.org
Nitric oxide (NO) has a wide range of potential applications in tumor therapy. However, a
targeted delivery system for NO donors has remained elusive, creating a bottleneck that …

From mechanism to therapy: The journey of CD24 in cancer

K Zhao, C Wu, X Li, M Niu, D Wu, X Cui… - Frontiers in …, 2024 - frontiersin.org
CD24 is a glycosylphosphatidylinositol-anchored protein that is expressed in a wide range
of tissues and cell types. It is involved in a variety of physiological and pathological …

CD24 as a potential therapeutic target in patients with B-cell leukemia and lymphoma: current insights

SL Christian - OncoTargets and Therapy, 2022 - pmc.ncbi.nlm.nih.gov
CD24 is a highly glycosylated glycophosphatidylinositol (GPI)-anchored protein that is
expressed in many types of differentiating cells and some mature cells of the immune system …

Development of a novel histone deacetylase-targeted near-infrared probe for hepatocellular carcinoma imaging and fluorescence image-guided surgery

C Tang, Y Du, Q Liang, Z Cheng, J Tian - Molecular Imaging and Biology, 2020 - Springer
Purpose Hepatocellular carcinoma (HCC) is a common cancer worldwide, and complete
surgical resection of diseased tissue is a reliable strategy to cure cancer. Fluorescence …