The human and non-human primate developmental GTEx projects
Many human diseases are the result of early developmental defects. As most paediatric
diseases and disorders are rare, children are critically underrepresented in research …
diseases and disorders are rare, children are critically underrepresented in research …
[HTML][HTML] Omics approaches to investigate the pathogenesis of suicide
Suicide is the second leading cause of death in US adolescents and young adults and is
generally associated with a psychiatric disorder. Suicidal behavior has a complex etiology …
generally associated with a psychiatric disorder. Suicidal behavior has a complex etiology …
Private information leakage from single-cell count matrices
The increase in publicly available human single-cell datasets, encompassing millions of
cells from many donors, has significantly enhanced our understanding of complex biological …
cells from many donors, has significantly enhanced our understanding of complex biological …
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
LA Huuki-Myers, A Spangler, NJ Eagles… - Science, 2024 - science.org
The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …
context of its histological layers. However, emerging spatial transcriptomic technologies …
Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseases
Neurodegenerative and neuropsychiatric diseases impose a significant societal and public
health burden. However, our understanding of the molecular mechanisms underlying these …
health burden. However, our understanding of the molecular mechanisms underlying these …
Brain aging and rejuvenation at single-cell resolution
Brain aging leads to a decline in cognitive function and a concomitant increase in the
susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases …
susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases …
Chromatin accessibility provides a window into the genetic etiology of human brain disease
Neuropsychiatric and neurodegenerative diseases have a significant genetic component.
Risk variants often affect the noncoding genome, altering cis-regulatory elements (CREs) …
Risk variants often affect the noncoding genome, altering cis-regulatory elements (CREs) …
Unraveling aging from transcriptomics
Y Huang, S Zhu, S Yao, H Zhai, C Liu, JDJ Han - Trends in Genetics, 2024 - cell.com
Research into aging constitutes a pivotal endeavor aimed at elucidating the underlying
biological mechanisms governing aging and age-associated diseases, as well as promoting …
biological mechanisms governing aging and age-associated diseases, as well as promoting …
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
A meta-genome-wide association study across eight psychiatric disorders has highlighted
the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms …
the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms …
Comparative single‐cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in …
Y **ao, X Chen, Z Chen, W Dai, X Hu, S Zhang… - Aging …, 2024 - Wiley Online Library
Reactive oxygen species (ROS) and oxidative stress accelerate cellular aging, but their
impact on different tissues varies. The cornea, known for its robust antioxidant defense …
impact on different tissues varies. The cornea, known for its robust antioxidant defense …