Small RNAs in bacteria and archaea: who they are, what they do, and how they do it
Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …
[HTML][HTML] Comparing bioinformatic gene expression profiling methods: microarray and RNA-Seq
Understanding the control of gene expression is critical for our understanding of the
relationship between genotype and phenotype. The need for reliable assessment of …
relationship between genotype and phenotype. The need for reliable assessment of …
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis
For decades, identifying the regions of a bacterial chromosome that are necessary for
viability has relied on map** integration sites in libraries of random transposon mutants to …
viability has relied on map** integration sites in libraries of random transposon mutants to …
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance
H Zhang, D Li, L Zhao, J Fleming, N Lin, T Wang… - Nature …, 2013 - nature.com
The worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant
(XDR) tuberculosis threatens to make this disease incurable,. Drug resistance mechanisms …
(XDR) tuberculosis threatens to make this disease incurable,. Drug resistance mechanisms …
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis
Q Wang, HIM Boshoff, JR Harrison, PC Ray, SR Green… - Science, 2020 - science.org
Mycobacterium tuberculosis has an unusual outer membrane that lacks canonical porin
proteins for the transport of small solutes to the periplasm. We discovered that 3, 3-bis-di …
proteins for the transport of small solutes to the periplasm. We discovered that 3, 3-bis-di …
Genome-wide map** of transcriptional start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis
Deciphering physiological changes that mediate transition of Mycobacterium tuberculosis
between replicating and nonreplicating states is essential to understanding how the …
between replicating and nonreplicating states is essential to understanding how the …
Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis
YJ Zhang, TR Ioerger, C Huttenhower, JE Long… - 2012 - journals.plos.org
Identifying genomic elements required for viability is central to our understanding of the
basic physiology of bacterial pathogens. Recently, the combination of high-density …
basic physiology of bacterial pathogens. Recently, the combination of high-density …
Mycobacterial dormancy systems and host responses in tuberculosis
Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …
[HTML][HTML] The Mtb proteome library: a resource of assays to quantify the complete proteome of Mycobacterium tuberculosis
Research advancing our understanding of Mycobacterium tuberculosis (Mtb) biology and
complex host-Mtb interactions requires consistent and precise quantitative measurements of …
complex host-Mtb interactions requires consistent and precise quantitative measurements of …
The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis
where it controls expression of approximately 2% of the genes, including those for the ESX-1 …
where it controls expression of approximately 2% of the genes, including those for the ESX-1 …