Cracking the code: reprogramming the genetic script in prokaryotes and eukaryotes to harness the power of noncanonical amino acids
C Jann, S Giofré, R Bhattacharjee, EA Lemke - Chemical Reviews, 2024 - ACS Publications
Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …
decades. Incorporating these noncanonical amino acids into proteins enables many …
Proteome complexity and the forces that drive proteome imbalance
The cellular proteome is a complex microcosm of structural and regulatory networks that
requires continuous surveillance and modification to meet the dynamic needs of the cell. It is …
requires continuous surveillance and modification to meet the dynamic needs of the cell. It is …
Cellular stress associated with aneuploidy
Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …
Translational fidelity and mistranslation in the cellular response to stress
Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …
Transfer RNAs: diversity in form and function
As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …
structure and function are central to all studies of biology. Yet the complexities of their …
mRNA translation gone awry: translation fidelity and neurological disease
M Kapur, SL Ackerman - Trends in Genetics, 2018 - cell.com
Errors during mRNA translation can lead to a reduction in the levels of functional proteins
and an increase in deleterious molecules. Advances in next-generation sequencing have …
and an increase in deleterious molecules. Advances in next-generation sequencing have …
Phenotypic mutations contribute to protein diversity and shape protein evolution
Errors in DNA replication generate genetic mutations, while errors in transcription and
translation lead to phenotypic mutations. Phenotypic mutations are orders of magnitude …
translation lead to phenotypic mutations. Phenotypic mutations are orders of magnitude …
Errors in translational decoding: tRNA wobbling or misincorporation?
As the central dogma of molecular biology, genetic information flows from DNA through
transcription into RNA followed by translation of the message into protein by transfer RNAs …
transcription into RNA followed by translation of the message into protein by transfer RNAs …
Function and origin of mistranslation in distinct cellular contexts
Mistranslation describes errors during protein synthesis that prevent the amino acid
sequences specified in the genetic code from being reflected within proteins. For a long …
sequences specified in the genetic code from being reflected within proteins. For a long …
Codon misreading tRNAs promote tumor growth in mice
Deregulation of tRNAs, aminoacyl-tRNA synthetases and tRNA modifying enzymes are
common in cancer, raising the hypothesis that protein synthesis efficiency and accuracy …
common in cancer, raising the hypothesis that protein synthesis efficiency and accuracy …