microRNA strand selection: Unwinding the rules

JC Medley, G Panzade… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …

A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome

B Fromm, T Billipp, LE Peck, M Johansen… - Annual review of …, 2015 - annualreviews.org
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …

miRBase: annotating high confidence microRNAs using deep sequencing data

A Kozomara, S Griffiths-Jones - Nucleic acids research, 2014 - academic.oup.com
We describe an update of the miRBase database (http://www. mirbase. org/), the primary
microRNA sequence repository. The latest miRBase release (v20, June 2013) contains 24 …

Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation

JO Westholm, P Miura, S Olson, S Shenker, B Joseph… - Cell reports, 2014 - cell.com
Circularization was recently recognized to broadly expand transcriptome complexity. Here,
we exploit massive Drosophila total RNA-sequencing data,> 5 billion paired-end reads …

Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism

M Ouimet, S Koster, E Sakowski, B Ramkhelawon… - Nature …, 2016 - nature.com
Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the
lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source …

[HTML][HTML] Origins and mechanisms of miRNAs and siRNAs

RW Carthew, EJ Sontheimer - Cell, 2009 - cell.com
Over the last decade,∼ 20–30 nucleotide RNA molecules have emerged as critical
regulators in the expression and function of eukaryotic genomes. Two primary categories of …

Evolution of microRNA diversity and regulation in animals

E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …

Regulation of the MIR155 host gene in physiological and pathological processes

TS Elton, H Selemon, SM Elton, NL Parinandi - Gene, 2013 - Elsevier
MicroRNAs (miRNAs), a family of small nonprotein-coding RNAs, play a critical role in
posttranscriptional gene regulation by acting as adaptors for the miRNA-induced silencing …

Uncovering small RNA-mediated responses to phosphate deficiency in Arabidopsis by deep sequencing

LC Hsieh, SI Lin, ACC Shih, JW Chen, WY Lin… - Plant …, 2009 - academic.oup.com
Recent studies have demonstrated the important role of plant microRNAs (miRNAs) under
nutrient deficiencies. In this study, deep sequencing of Arabidopsis (Arabidopsis thaliana) …

The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways

MC Kuo, SCH Liu, YF Hsu, RM Wu - Journal of biomedical science, 2021 - Springer
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …