Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …

Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …

The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has
accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates …

Transformed, oncogenic precursors, possessing both defining neural-stem-cell properties
and the ability to initiate intracerebral tumours, have been identified in human brain cancers …

Large numbers of new neurons are born continuously in the adult subventricular zone
(SVZ). The molecular niche of SVZ stem cells is poorly understood. Here, we show that the …

The develo** dorsomedial telencephalon includes the medial pallium, which goes on to
form the hippocampus. Generating a reliable source of human hippocampal tissue is an …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Males and females generally have different finger proportions. In males, digit 2 is shorter
than digit 4, but in females digit 2 is the same length or longer than digit 4. The second-to …

The spatio-temporal timing of the last round of mitosis, followed by the migration of
neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is …

The cerebral cortex of the human brain is a sheet of about 10 billion neurons divided into
discrete subdivisions or areas that process particular aspects of sensation, movement, and …