Cancer, currently the leading cause of death in the population aged less than 85 years,
poses a significant global disease burden and is anticipated to continue to increase in …

The adrenal gland is a vital endocrine organ, and adrenal steroid synthesis and secretion
are closely regulated by the hypothalamic–pituitary–adrenal (HPA) axis in response to …

Long-term consequences of anesthetic exposure in humans are not well understood. It is
possible that alterations in brain function occur beyond the initial anesthetic administration …

Critically ill patients have elevated plasma cortisol concentrations, in proportion to illness
severity. This was traditionally attributed exclusively to a central activation of the …

Animal imaging of brain systems offers exciting opportunities to better understand the
neurobiology of pain and analgesia. Overall functional studies have lagged behind human …

The human physiological response “to stress” includes all metabolic and hormonal changes
produced by a traumatic event at the micro or macro cellular levels. The main goal of the …

Prolonged normothermic ex vivo heart perfusion could transform cardiac transplantation. To
help identify perfusate components that might enable long-term perfusion, we evaluated the …

This prospective randomized controlled trial aimed to compare the effects of sevoflurane and
propofol anesthesia on the occurrence of acute kidney injury (AKI) following lung …

Despite increased cortisol production, adrenal function may be disturbed, and exogenous
ACTH (cosyntropin) may result in little or no cortisol synthesis. 20, 21 Relative adrenal …

Imaging pain pathways in rats offers a tool to investigate CNS systems in acute and chronic
rodent models of pain, neural plasticity associated with the latter, and the opportunity to …