Narrative review of topiramate: clinical uses and pharmacological considerations

NZ Pearl, CP Babin, NT Catalano, JC Blake… - Advances in …, 2023 - Springer
Due to the diverse mechanisms of action of antiseizure drugs, there has been a rise in
prescriptions of these drugs for non-epileptic pathologies. One drug that is now being used …

[HTML][HTML] Levetiracetam, from broad-spectrum use to precision prescription: A narrative review and expert opinion

AC de Castro, FA Nascimento… - … : European Journal of …, 2023 - Elsevier
Levetiracetam (LEV) is an antiseizure medication (ASM) whose mechanism of action
involves the modulation of neurotransmitters release through binding to the synaptic vesicle …

Adverse event profiles of antiseizure medications and the impact of coadministration on drug tolerability in adults with epilepsy

LM Willems, M van der Goten, F von Podewils, S Knake… - CNS drugs, 2023 - Springer
Background Antiseizure medication (ASM) as monotherapy or in combination is the
treatment of choice for most patients with epilepsy. Therefore, knowledge about the typical …

Unemployment and early retirement among patients with epilepsy–a study on predictors, resilience factors and occupational reintegration measures

LM Willems, JP Zöllner, L Hamann, S Knake, S Kovac… - Epilepsy & Behavior, 2023 - Elsevier
The primary aim of this study was to identify predictors and resilience factors for
unemployment and early retirement in patients with epilepsy of working age based on data …

Supply problems of antiseizure medication are common among epilepsy patients in Germany

C Mann, M Maltseva, F von Podewils, S Knake… - Epilepsy & Behavior, 2023 - Elsevier
Objective To evaluate the frequency of reported antiseizure medication (ASM) supply
problems among patients with epilepsy (PWE) in Germany. Methods The Epi2020 study was …

Clinical and economic implications of epilepsy management across treatment lines in Spain: a real-life database analysis

R Toledano, V Villanueva, M Toledo, J Sabaniego… - Journal of …, 2023 - Springer
Background Epilepsy is a chronic brain disease characterized by recurrent seizures. We
investigated real-world management of epilepsy across treatment lines in Spain, including …

Transfer of anticonvulsants and lithium into amniotic fluid, umbilical cord blood & breast milk: A systematic review & combined analysis

CT Schmidt, KM Deligiannidis… - Progress in Neuro …, 2023 - Elsevier
Objective Data on the ability of anticonvulsants and lithium to enter fetal and newborn
circulation has become increasingly available; here we estimated penetration ratios in a …

[HTML][HTML] Persistent knowledge gaps between 2005 and 2020 in women with epilepsy: Comparison of multicenter studies from Germany

C Mann, E Zinger, B Schmitz, T May, F Rosenow… - Seizure, 2022 - Elsevier
Objective Epilepsy is a chronic condition that can affect patients of all ages. Women with
epilepsy (WWE) require access to specific counseling and information regarding issues …

Prescription trends in anti-seizure medications for adult patients with epilepsy in Japan: A retrospective cohort study using the database of health insurance claims …

K **, T Obara, K Hirano, D Hirai, M Kiuchi, T Tanaka… - Epilepsy & Behavior, 2022 - Elsevier
Objective To investigate whether newer anti-seizure medications (ASMs) are widely
prescribed for a range of adult patients in Japan, including patients with previously and …

Adverse events of undiluted intravenous push levetiracetam–A prospective observational study

JA Summerlin, N Scaturo, JA Lund, KM Wang… - The American Journal of …, 2023 - Elsevier
Background In patients who experience a seizure, the seizure duration is a strong indicator
of prognosis. Thus, reducing time to antiepileptic medications in patients who are actively …