Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C (ut) annabinoid” System
The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted
homeostatic regulator, which influences a wide-variety of physiological processes all over …
homeostatic regulator, which influences a wide-variety of physiological processes all over …
[PDF][PDF] Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for …
KL Hon, YC Tsang, NH Pong… - Hong Kong …, 2015 - pdfs.semanticscholar.org
Objectives: To investigate patient acceptability, efficacy, and skin biophysiological effects of
a cream/cleanser combination for childhood atopic dermatitis. Design: Case series. Setting …
a cream/cleanser combination for childhood atopic dermatitis. Design: Case series. Setting …
N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: results of a randomized, double-blind, controlled study in 60 patients
C Yuan, XM Wang, A Guichard, YM Tan… - … Interventions in Aging, 2014 - Taylor & Francis
Background Asteatotic eczema (AE) is characterized by itchy, dry, rough, and scaling skin.
The treatments for AE are mainly emollients, usually containing urea, lactic acid, or a lactate …
The treatments for AE are mainly emollients, usually containing urea, lactic acid, or a lactate …
Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti‐inflammatory lipid N‐acylethanolamine
L Liang, R Takamiya, Y Miki, K Heike… - The FASEB …, 2022 - Wiley Online Library
Psoriasis is an inflammatory disorder characterized by keratinocyte hyper‐proliferation and
Th17‐type immune responses. However, the roles of bioactive lipids and the regulation of …
Th17‐type immune responses. However, the roles of bioactive lipids and the regulation of …
Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial
M Khalaj, A Saghazadeh, E Shirazi… - Journal of psychiatric …, 2018 - Elsevier
Inflammation as well as glutamate excitotoxicity have been proposed to participate in the
propagation of autism. Palmitoylethanolamide (PEA) is an endocannabinoid proven to …
propagation of autism. Palmitoylethanolamide (PEA) is an endocannabinoid proven to …
Advances in the discovery of N-acylethanolamine acid amidase inhibitors
T Bandiera, S Ponzano, D Piomelli - Pharmacological research, 2014 - Elsevier
N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase that hydrolyzes saturated
or monounsaturated fatty acid ethanolamides, such as palmitoylethanolamide (PEA) and …
or monounsaturated fatty acid ethanolamides, such as palmitoylethanolamide (PEA) and …
Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure–activity relationship (SAR) studies
A Nuzzi, A Fiasella, JA Ortega, C Pagliuca… - European journal of …, 2016 - Elsevier
Cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl] carbamate (3b) is a potent, selective and
systemically active inhibitor of intracellular NAAA activity, which produces profound anti …
systemically active inhibitor of intracellular NAAA activity, which produces profound anti …
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships
A Duranti, A Tontini, F Antonietti… - Journal of medicinal …, 2012 - ACS Publications
The β-lactone ring of N-(2-oxo-3-oxetanyl) amides, a class of N-acylethanolamine acid
amidase (NAAA) inhibitors endowed with anti-inflammatory properties, is responsible for …
amidase (NAAA) inhibitors endowed with anti-inflammatory properties, is responsible for …
Synthesis and Structure–Activity Relationship (SAR) of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N-Acylethanolamine Acid Amidase (NAAA) …
S Ponzano, F Bertozzi, L Mengatto… - Journal of medicinal …, 2013 - ACS Publications
N-Acylethanolamine acid amidase (NAAA) is a lysosomal cysteine hydrolase involved in the
degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of …
degradation of saturated and monounsaturated fatty acid ethanolamides (FAEs), a family of …
Interaction of epicutaneously applied lipids with stratum corneum depends on the presence of either emulsifiers or hydrogenated phosphatidylcholine
J Wohlrab, T Klapperstück, HW Reinhardt… - Skin Pharmacology and …, 2010 - karger.com
The barrier function of the stratum corneum (SC) significantly determines the interaction of
epicutaneously applied substances with the skin organ. Although the exact molecular …
epicutaneously applied substances with the skin organ. Although the exact molecular …