Reactive oxygen species (ROS) are produced at low levels in mammalian cells by various
metabolic processes, such as oxidative phosphorylation by the mitochondrial respiratory …

Lipids are fundamental building blocks of all cells and play important roles in the
pathogenesis of different diseases, including inflammation, autoimmune disease, cancer …

Lipid accumulation in podocytes is a major determinant of diabetic kidney disease (DKD)
and identification of potential therapeutic targets by mediating podocyte lipid metabolism …

Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic
nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold …

Previous studies suggested a beneficial effect of natriuretic peptides in animal models of
cardiovascular disease, but the role of natriuretic peptide receptor C (NPRC) in the …

UVA radiation is a major environmental stress on skin, causing acute and chronic
photodamage. These responses are mediated by reactive oxygen species (ROS), although …

Activation of cells by receptor-and nonreceptor-mediated stimuli not only requires a change
in the activity of signaling proteins but also requires a reorganization of the topology of the …

Background/Aims: Although numerous studies have explored the mechanisms regulating
the enzyme activity of NADPH oxidase in diabetic nephropathy (DN), little information is …

Plasma sphingomyelin concentration is correlated with the development of atherosclerosis.
It has been found to exist in significantly higher concentrations in aortic plaque. This appears …

An increasing number of clinical and animal model studies indicate that activation of the
innate immune system and inflammatory mechanisms are important in the pathogenesis of …