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Emerging principles of cytokine pharmacology and therapeutics
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …
maintenance and resolution of immune responses. Although the unique ability of cytokines …
Decoding type I and III interferon signalling during viral infection
EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
STING: a master regulator in the cancer-immunity cycle
Y Zhu, X An, X Zhang, Y Qiao, T Zheng, X Li - Molecular cancer, 2019 - Springer
The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-
STING signaling and induces the production of type I interferons, which play critical roles in …
STING signaling and induces the production of type I interferons, which play critical roles in …
Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic
Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by
the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. We investigated five …
the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. We investigated five …
Type I interferons in autoimmune disease
MK Crow, M Olferiev, KA Kirou - Annual Review of Pathology …, 2019 - annualreviews.org
Type I interferons, which make up the first cytokine family to be described and are the
essential mediators of antivirus host defense, have emerged as central elements in the …
essential mediators of antivirus host defense, have emerged as central elements in the …
Interferons and viruses: an evolutionary arms race of molecular interactions
HH Hoffmann, WM Schneider, CM Rice - Trends in immunology, 2015 - cell.com
Over half a century has passed since interferons (IFNs) were discovered and shown to
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …
The role of type I interferons in the pathogenesis and treatment of COVID-19
G Schreiber - Frontiers in immunology, 2020 - frontiersin.org
Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by
Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became …
Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became …
Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines
Vaccination against measles, mumps, and rubella (MMR) and yellow fever (YF) with live
attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR …
attenuated viruses can rarely cause life-threatening disease. Severe illness by MMR …
The molecular basis for differential type I interferon signaling
G Schreiber - Journal of Biological Chemistry, 2017 - jbc.org
Type I interferons (IFN-1) are cytokines that affect the expression of thousands of genes,
resulting in profound cellular changes. IFN-1 activates the cell by dimerizing its two-receptor …
resulting in profound cellular changes. IFN-1 activates the cell by dimerizing its two-receptor …
Insights into cytokine–receptor interactions from cytokine engineering
Cytokines exert a vast array of immunoregulatory actions critical to human biology and
disease. However, the desired immunotherapeutic effects of native cytokines are often …
disease. However, the desired immunotherapeutic effects of native cytokines are often …