When migrating away from a primary tumour, cancer cells interact with and remodel the
extracellular matrix (ECM). Matrix metalloproteinases (MMPs), and in particular the …

The polarized distribution of functions in polarized cells requires the coordinated interaction
of three machineries that modify the basic mechanisms of intracellular protein trafficking and …

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers.
Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the …

The Arp2/3 complex is an actin nucleator that plays a critical role in many cellular processes.
Its activities are regulated by nucleation-promoting factors (NPFs) that function primarily …

In addition to its ability to accelerate filament assembly, which is common to formins, INF2 is
a formin protein with the unique biochemical ability to accelerate actin filament …

A number of protein toxins produced by bacteria and plants enter eukaryotic cells and inhibit
protein synthesis enzymatically. These toxins include the plant toxin ricin and the bacterial …

Apolipoprotein B (APOB) is a constituent of unique lipoprotein particles (LPPs) produced in
the retinal pigment epithelium (RPE), which separates the neural retina from Bruch's …

Cytoskeletal proteins, including microfilaments, microtubules, and intermediate filaments,
play a pivotal role in the treatment of cancer, as their regulation by small molecules arrests …

EHBP-1 (Ehbp1) is a conserved regulator of endocytic recycling, acting as an effector of
small GTPases including RAB-10 (Rab10). Here we present evidence that EHBP-1 …

The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the
transport of intracellular materials, the maintenance of cell polarity, and the regulation of …