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Functionalizing DNA origami to investigate and interact with biological systems
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …
dynamic properties and nanoscale control. These nanostructures enable complex …
In vivo applications of bioorthogonal reactions: chemistry and targeting mechanisms
MMA Mitry, F Greco, HMI Osborn - Chemistry–A European …, 2023 - Wiley Online Library
Bioorthogonal chemistry involves selective biocompatible reactions between functional
groups that are not normally present in biology. It has been used to probe biomolecules in …
groups that are not normally present in biology. It has been used to probe biomolecules in …
Single-cell analysis and sorting using droplet-based microfluidics
We present a droplet-based microfluidics protocol for high-throughput analysis and sorting
of single cells. Compartmentalization of single cells in droplets enables the analysis of …
of single cells. Compartmentalization of single cells in droplets enables the analysis of …
Droplet microfluidics—A tool for single‐cell analysis
HN Joensson… - Angewandte Chemie …, 2012 - Wiley Online Library
Droplet microfluidics allows the isolation of single cells and reagents in monodisperse
picoliter liquid capsules and manipulations at a throughput of thousands of droplets per …
picoliter liquid capsules and manipulations at a throughput of thousands of droplets per …
Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology
Microdroplets in microfluidics offer a great number of opportunities in chemical and
biological research. They provide a compartment in which species or reactions can be …
biological research. They provide a compartment in which species or reactions can be …
Analytical detection techniques for droplet microfluidics—A review
Y Zhu, Q Fang - Analytica chimica acta, 2013 - Elsevier
In the last decade, droplet-based microfluidics has undergone rapid progress in the fields of
single-cell analysis, digital PCR, protein crystallization and high throughput screening. It has …
single-cell analysis, digital PCR, protein crystallization and high throughput screening. It has …
A review of the theory, methods and recent applications of high-throughput single-cell droplet microfluidics
TP Lagus, JF Edd - Journal of Physics D: Applied Physics, 2013 - iopscience.iop.org
Most cell biology experiments are performed in bulk cell suspensions where cell secretions
become diluted and mixed in a contiguous sample. Confinement of single cells to small …
become diluted and mixed in a contiguous sample. Confinement of single cells to small …
Quantification of protein interactions and solution transport using high-density GMR sensor arrays
Monitoring the kinetics of protein interactions on a high-density sensor array is vital to drug
development and proteomic analysis. Label-free kinetic assays based on surface plasmon …
development and proteomic analysis. Label-free kinetic assays based on surface plasmon …
A CRISPR-Cas12a-powered magnetic relaxation switching biosensor for the sensitive detection of Salmonella
Magnetic relaxation switching (MRS) biosensors are attractive in the field of food safety
owing to their simplicity and high signal-to-noise ratio. But they are less in sensitivity and …
owing to their simplicity and high signal-to-noise ratio. But they are less in sensitivity and …
Length-independent DNA packing into nanopore zero-mode waveguides for low-input DNA sequencing
Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing
exhibits longer read lengths than conventional methods, less GC bias, and the ability to read …
exhibits longer read lengths than conventional methods, less GC bias, and the ability to read …