Curcumin formulations for better bioavailability: what we learned from clinical trials thus far?

M Hegde, S Girisa, B BharathwajChetty, R Vishwa… - ACS …, 2023 - ACS Publications
Curcumin has been credited with a wide spectrum of pharmacological properties for the
prevention and treatment of several chronic diseases such as arthritis, autoimmune …

Role of turmeric and curcumin in prevention and treatment of chronic diseases: Lessons learned from clinical trials

AB Kunnumakkara, M Hegde, D Parama… - ACS Pharmacology & …, 2023 - ACS Publications
Turmeric (Curcuma longa) has been used for thousands of years for the prevention and
treatment of various chronic diseases. Curcumin is just one of> 200 ingredients in turmeric …

Phytochemicals as invaluable sources of potent antimicrobial agents to combat antibiotic resistance

R Jadimurthy, S Jagadish, SC Nayak, S Kumar… - Life, 2023 - mdpi.com
Simple Summary Many microorganisms develop resistance to drugs through different
mechanisms, and this process is called antimicrobial resistance. It is highly essential to …

[HTML][HTML] Curcumin, inflammation, and neurological disorders: How are they linked?

P Garodia, M Hegde, AB Kunnumakkara… - Integrative Medicine …, 2023 - Elsevier
Background: Despite the extensive research in recent years, the current treatment modalities
for neurological disorders are suboptimal. Curcumin, a polyphenol majorly found in …

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

S Kumar, SO Mathew, RP Aharwal, HS Tulli… - Pharmaceuticals, 2023 - mdpi.com
Cancer represents the second most deadly disease and one of the most important public
health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy …

Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review

BL Sailo, L Liu, S Chauhan, S Girisa, M Hegde, L Liang… - Cancers, 2024 - mdpi.com
Simple Summary Recent oncological research highlights the promising role of naturally
derived compounds in cancer prevention and treatment. Sulforaphane (SFN), a …

Targeting MCL1 with Sanggenon C overcomes MCL1-driven adaptive chemoresistance via dysregulation of autophagy and endoplasmic reticulum stress in cervical …

W Sun, H Cai, K Zhang, H Cui, E Zhao - Phytomedicine, 2024 - Elsevier
Background Cervical cancer ranks as one of the most prevalent malignancies among
women worldwide and poses a significant threat to health and quality of life. MCL1 is an …

CXCR4 expression is elevated in TNBC patient derived samples and Z-guggulsterone abrogates tumor progression by targeting CXCL12/CXCR4 signaling axis in …

N Gupta, CD Mohan, MK Shanmugam, YY Jung… - Environmental …, 2023 - Elsevier
Environmental factors such as exposure to ionizing radiations, certain environmental
pollutants, and toxic chemicals are considered as risk factors in the development of breast …

Leonurine ameliorates the STAT3 pathway through the upregulation of SHP-1 to retard the growth of hepatocellular carcinoma cells

YY Jung, C Kim, MK Shanmugam, A Deivasigamani… - Cellular …, 2024 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that directs
the transcription of genes involved in the promotion of cell survival and proliferation …

Exploring the nexus of nuclear receptors in hematological malignancies

MK Manickasamy, A Sajeev… - Cellular and Molecular …, 2024 - Springer
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood,
bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and …