This Perspective is a continuation of our analysis of US FDA-approved small-molecule drugs
(1938–2012) containing nitrogen heterocycles. In this study we report drug structure and …

Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Insomnia disorder comprises symptoms during night and day that strongly affect quality of
life and wellbeing. Prolonged sleep latency, difficulties to maintain sleep and early morning …

Background Daytime functioning is impaired in people with insomnia disorder. Currently
available dual orexin receptor antagonists have shown efficacy in insomnia disorder, but do …

While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

The concept of sleep health provides a positive holistic framing of multiple sleep
characteristics, including sleep duration, continuity, timing, alertness, and satisfaction. Sleep …

Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …

This commentary highlights the critical role of sleep as a public health issue, particularly
during a stressful life period such as the COVID-19 pandemic, and provides evidence-based …