Protein ensembles link genotype to phenotype
Classically, phenotype is what is observed, and genotype is the genetic makeup. Statistical
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …
studies aim to project phenotypic likelihoods of genotypic patterns. The traditional genotype …
Impact of protein conformational diversity on AlphaFold predictions
Motivation After the outstanding breakthrough of AlphaFold in predicting protein 3D models,
new questions appeared and remain unanswered. The ensemble nature of proteins, for …
new questions appeared and remain unanswered. The ensemble nature of proteins, for …
[HTML][HTML] Essential site scanning analysis: A new approach for detecting sites that modulate the dispersion of protein global motions
Despite the wealth of methods developed for exploring the molecular basis of allostery in
biomolecular systems, there is still a need for structure-based predictive tools that can …
biomolecular systems, there is still a need for structure-based predictive tools that can …
The roles of highly conserved, non‐catalytic residues in class A β‐lactamases
A Chikunova, M Ubbink - Protein Science, 2022 - Wiley Online Library
Evolution minimizes the number of highly conserved amino acid residues in proteins to
ensure evolutionary robustness and adaptability. The roles of all highly conserved, non …
ensure evolutionary robustness and adaptability. The roles of all highly conserved, non …
Nature to nurture-identifying phytochemicals from Indian medicinal plants as prophylactic medicine by rational screening to be potent against multiple drug targets of …
PK Parida, D Paul, D Chakravorty - 2020 - chemrxiv.org
The COVID-19 pandemic resulted in millions of people being quarantined, impacting the
world economy and health sector. There is no existing proven treatment for this disease. It …
world economy and health sector. There is no existing proven treatment for this disease. It …
Impact of phylogeny on the inference of functional sectors from protein sequence data
Statistical analysis of multiple sequence alignments of homologous proteins has revealed
groups of coevolving amino acids called sectors. These groups of amino-acid sites feature …
groups of coevolving amino acids called sectors. These groups of amino-acid sites feature …
Revealing evolutionary constraints on proteins through sequence analysis
Statistical analysis of alignments of large numbers of protein sequences has revealed
“sectors” of collectively coevolving amino acids in several protein families. Here, we show …
“sectors” of collectively coevolving amino acids in several protein families. Here, we show …
Potato E3 ubiquitin ligase PUB27 negatively regulates drought tolerance by mediating stomatal movement
X Tang, S Ghimire, W Liu, X Fu, H Zhang… - Plant Physiology and …, 2020 - Elsevier
The ubiquitin-proteasome system (UPS) is one of the main ways of eukaryotic protein
degradation and post-translational modification. It has proven as an essential process for …
degradation and post-translational modification. It has proven as an essential process for …
A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders
A Sobitan, B Gebremedhin, Q Yao, G **e… - JCO Clinical Cancer …, 2024 - ascopubs.org
PURPOSE Thyroid peroxidase (TPO) is essential for the synthesis of thyroid hormones.
However, specific mutations render TPO antigenic and prone to autoimmune attacks leading …
However, specific mutations render TPO antigenic and prone to autoimmune attacks leading …
Unveiling a Hidden Pocket in HIV‐1 Protease: New Insights Into Retroviral Protease Cantilever‐Tip Region Characteristics
The HIV‐1 protease is critical for the process of viral maturation and as such, it is one of the
most well characterized proteins in the Protein Data Bank. There is some evidence to …
most well characterized proteins in the Protein Data Bank. There is some evidence to …