Cancers of the colon are most common in the Western world. In majority of these cases,
there is no familial history and sporadic gene damage seems to play an important role in the …

Toxicogenomics is proposed to be a useful tool in human health risk assessment. However,
a systematic comparison of traditional risk assessment approaches with those applying …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Great interest
persists in useful therapeutic targets in GBM. Aberrant expression of long non-coding RNAs …

Background X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing
in female cells and allows X chromosome equilibration with males. X inactive-specific …

We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to
mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease …

Modern diets, which often feature high levels of fat and charcoal-grilled meat, contribute to
the pathogenesis of obesity and non-alcoholic fatty liver disease (NAFLD), resulting in liver …

Chemical modifications of RNA molecules have gained increasing attention since evidence
emerged for their substantive roles in a range of biological processes, such as the stability …

Smoking is a major risk factor for atherosclerosis. In this study, we evaluated the effects of
benzo [a] pyrene (BaP, a prominent component of tobacco smoke) on the function and pro …

Test batteries to screen chemicals for mutagenic hazard include several endpoints regarded
as effective for detecting genotoxic carcinogens. Traditional in vivo methods primarily …

Benzo [a] pyrene (B [a] P), a group 1 carcinogen, induces mutagenic DNA adducts. Myricetin
is present in many natural foods with diverse biological activities, such as anti-oxidative and …