Structures and functions of short argonautes
Argonaute proteins (Agos) represent a highly conserved family of proteins prevalent in all
domains of life and have been implicated in various biological processes. Based on the …
domains of life and have been implicated in various biological processes. Based on the …
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system
L Guo, P Huang, Z Li, YC Shin, P Yan, M Lu… - Nature Chemical …, 2024 - nature.com
Short prokaryotic Ago accounts for most prokaryotic Argonaute proteins (pAgos) and is
involved in defending bacteria against invading nucleic acids. Short pAgo associated with …
involved in defending bacteria against invading nucleic acids. Short pAgo associated with …
Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute
X Gao, K Shang, K Zhu, L Wang, Z Mu, X Fu, X Yu… - Nature, 2024 - nature.com
Argonaute (Ago) proteins mediate RNA-or DNA-guided inhibition of nucleic acids,. Although
the mechanisms used by eukaryotic Ago proteins and long prokaryotic Ago proteins (pAgos) …
the mechanisms used by eukaryotic Ago proteins and long prokaryotic Ago proteins (pAgos) …
Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches
The TIR (Toll/interleukin-1 receptor) domain represents a vital structural element shared by
proteins with roles in immunity signalling pathways across phyla (from humans and plants to …
proteins with roles in immunity signalling pathways across phyla (from humans and plants to …
Nucleic acid mediated activation of a short prokaryotic argonaute immune system
A short prokaryotic Argonaute (pAgo) TIR-APAZ (SPARTA) defense system, activated by
invading DNA to unleash its TIR domain for NAD (P)+ hydrolysis, was recently identified in …
invading DNA to unleash its TIR domain for NAD (P)+ hydrolysis, was recently identified in …
Asgard archaea defense systems and their roles in the origin of eukaryotic immunity
Dozens of new antiviral systems have been recently characterized in bacteria. Some of
these systems are present in eukaryotes and appear to have originated in prokaryotes, but …
these systems are present in eukaryotes and appear to have originated in prokaryotes, but …
Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA
G Finocchio, B Koopal, A Potocnik… - Nucleic acids …, 2024 - academic.oup.com
In both prokaryotic and eukaryotic innate immune systems, TIR domains function as
NADases that degrade the key metabolite NAD+ or generate signaling molecules. Catalytic …
NADases that degrade the key metabolite NAD+ or generate signaling molecules. Catalytic …
DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity
M Prostova, A Kanevskaya, V Panteleev… - Nature …, 2024 - nature.com
Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect
and cleave invader nucleic acids using complementary guides and the nuclease activities of …
and cleave invader nucleic acids using complementary guides and the nuclease activities of …
Insights into the modulation of bacterial NADase activity by phage proteins
H Yin, X Li, X Wang, C Zhang, J Gao, G Yu… - Nature …, 2024 - nature.com
Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …
The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein
E Manakova, E Golovinas, R Pocevičiūtė… - Nucleic Acids …, 2024 - academic.oup.com
Argonaute (Ago) proteins are present in all three domains of life (bacteria, archaea and
eukaryotes). They use small (15–30 nucleotides) oligonucleotide guides to bind …
eukaryotes). They use small (15–30 nucleotides) oligonucleotide guides to bind …