The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases

A DeMaio, S Mehrotra, K Sambamurti… - Journal of …, 2022 - Springer
The adaptive immune system and associated inflammation are vital in surveillance and host
protection against internal and external threats, but can secondarily damage host tissues …

Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments

GOB Ghanem, LK Wareham, DJ Calkins - Progress in Retinal and Eye …, 2024 - Elsevier
Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision
loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain …

[HTML][HTML] Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

G Tezel - Progress in retinal and eye research, 2022 - Elsevier
Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an
impactful component of the multifactorial etiology of neurodegeneration in glaucoma. It has …

Therapeutic drugs and devices for tackling ocular hypertension and glaucoma, and need for neuroprotection and cytoprotective therapies

NA Sharif - Frontiers in pharmacology, 2021 - frontiersin.org
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

Adaptive immunity: new aspects of pathogenesis underlying neurodegeneration in glaucoma and optic neuropathy

S Jiang, M Kametani, DF Chen - Frontiers in immunology, 2020 - frontiersin.org
Glaucoma is a globally unmet medical challenge and the most prevalent neurodegenerative
disease, which permanently damages the optic nerve and retinal ganglion cells (RGCs) …

[HTML][HTML] Immunomodulatory and antioxidant drugs in glaucoma treatment

F Buonfiglio, N Pfeiffer, A Gericke - Pharmaceuticals, 2023 - mdpi.com
Glaucoma, a group of diseases characterized by progressive retinal ganglion cell loss,
cup** of the optic disc, and a typical pattern of visual field defects, is a leading cause of …

[HTML][HTML] Multi-omics approach for studying tears in treatment-naïve glaucoma patients

C Rossi, I Cicalini, MC Cufaro, L Agnifili… - International Journal of …, 2019 - mdpi.com
Primary open-angle glaucoma (POAG) represents the leading cause of irreversible
blindness worldwide and is a multifactorial, chronic neurodegenerative disease …

The role of neuroinflammation in glaucoma: an update on molecular mechanisms and new therapeutic options

T Rolle, A Ponzetto, L Malinverni - Frontiers in Neurology, 2021 - frontiersin.org
Glaucoma is a multifactorial optic neuropathy characterized by the continuous loss of retinal
ganglion cells, leading to progressive and irreversible visual impairment. In this minireview …

Glaucoma characterization by machine learning of tear metabolic fingerprinting

J Wu, M Xu, W Liu, Y Huang, R Wang, W Chen… - Small …, 2022 - Wiley Online Library
Glaucoma is a common optic neuropathy disease affecting over 76 million people. Both
timely diagnosis and progression monitoring are critical but challenging. Conventional …

Tumour-associated autoantibodies as prognostic cancer biomarkers-a review

D Sexauer, E Gray, P Zaenker - Autoimmunity reviews, 2022 - Elsevier
Throughout the process of carcinogenesis, autologous cells are transformed into cancer
cells, leading to changes in their protein expression profiles. It has been suggested that …