Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

[HTML][HTML] Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council

Y Renert-Yuval, JP Thyssen, R Bissonnette… - Journal of Allergy and …, 2021 - Elsevier
Atopic dermatitis (AD) is a common yet complex skin disease, posing a therapeutic
challenge with increasingly recognized different phenotypes among variable patient …

Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a phase 2b randomized clinical trial

E Guttman-Yassky, A Blauvelt, LF Eichenfield… - JAMA …, 2020 - jamanetwork.com
Importance Interleukin 13 (IL-13) is a central pathogenic mediator driving multiple features of
atopic dermatitis (AD) pathophysiology. Objective To evaluate the efficacy and safety of …

[HTML][HTML] Biomarkers in atopic dermatitis

D Bakker, M de Bruin-Weller, J Drylewicz… - Journal of Allergy and …, 2023 - Elsevier
Atopic dermatitis (AD) is a complex and highly heterogeneous inflammatory skin disease.
Given the highly heterogeneous character of AD, it is unlikely that every patient will respond …

Spatial transcriptomics combined with single‐cell RNA‐sequencing unravels the complex inflammatory cell network in atopic dermatitis

Y Mitamura, M Reiger, J Kim, Y **ao, D Zhakparov… - Allergy, 2023 - Wiley Online Library
Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease
with complex pathogenesis for which the cellular and molecular crosstalk in AD skin has not …

Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis

H He, R Bissonnette, J Wu, A Diaz, ESC Proulx… - Journal of Allergy and …, 2021 - Elsevier
Background Our current understanding of atopic dermatitis (AD) and psoriasis
pathophysiology is largely derived from skin biopsy studies that cause scarring and may be …

Th2/Th1 cytokine imbalance is associated with higher COVID-19 risk mortality

AB Pavel, JW Glickman, JR Michels… - Frontiers in …, 2021 - frontiersin.org
A major component of COVID-19 severe respiratory syndrome is the patient's immune
response to the SARS-CoV-2 virus and the consequential multi-organ inflammatory …

[HTML][HTML] Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

N Alkon, WM Bauer, T Krausgruber, I Goh… - Journal of Allergy and …, 2022 - Elsevier
Background Although ample knowledge exists about phenotype and function of cutaneous T
lymphocytes, much less is known about the lymphocytic components of the skin's innate …

The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature

AB Pavel, L Zhou, A Diaz, B Ungar, J Dan, H He… - Journal of the American …, 2020 - Elsevier
Background Moderate-to-severe atopic dermatitis (AD) is increasingly recognized as a
systemic disease, largely due to proteomic blood studies. There are growing efforts to …

Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options

T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …