Abstract RING-in-between-RING (RBR) E3 ligases are one class of E3 ligases that is
characterized by the unique RING-HECT hybrid mechanism to function with E2s to transfer …

Epidemiologic studies indicate a decreased incidence of most cancer types in Parkinson's
disease (PD) patients. However, some neoplasms are associated with a higher risk of …

Inulin as a natural polysaccharide regulates intestinal microorganisms, and improves the
immune and gastrointestinal function. In order to explore the effect of inulin on pulmonary …

Parkin for more than a decade has been portrayed as a neuroprotector gene is now
increasingly emerging as a multifaceted gene that can exert entirely opposite effects ie, both …

It is emerging that autophagy-related proteins regulate the adaptive response to DNA
damage in maintaining genome stability at multiple pathways. Here, we discuss recent …

The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body
of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin …

H. pylori is classified as a group I carcinogen by WHO because of its involvement in gastric
cancer development. Several reports have suggested anti-bacterial effects of menadione …

Background and purpose Increasing evidence suggests significant associations between
Parkinson disease (PD) and cancer risks. We conducted an updated review of studies that …

Malignant melanoma is a devastating skin cancer due to its severe drug resistance and
prompt metastasis. Piperlongumine is an anti-inflammation and tumor-suppressing natural …

Parkin (PARK2) deficiency is frequently observed in various cancers and potentially
promotes tumor progression. Here, we showed that Parkin expression is downregulated in …