The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Heart failure (HF) is a leading cause of morbidity and mortality across the world. Cardiac
fibrosis is associated with HF progression. Fibrosis is characterized by the excessive …

Background: Heart failure is the leading cause of mortality, morbidity, and health care
expenditures worldwide. Numerous studies have implicated GSK-3 (glycogen synthase …

Uncontrolled and excessive fibrosis after myocardial infarction (MI) in the peri-infarct zone
leads to left ventricular remodeling and deterioration of cardiac function. Inhibiting fibroblast …

Cardiovascular disease (CVD) is one of the major causes of mortality worldwide.
Inflammation is the underlying common mechanism involved in CVD. It has been recently …

Effective therapeutic strategies for myocardial ischemia/reperfusion (I/R) injury remain
elusive. Targeting reactive oxygen species (ROS) provides a practical approach to mitigate …

Aims Maladaptive ventricular remodeling is a major cause of ventricular arrhythmias
following myocardial infarction (MI) and adversely impacts the quality of life of affected …

Acute myocardial infarction (AMI) is one of the leading causes of death worldwide and
treatment costs pose a major burden on the global health care system. Despite the variety of …

Degenerative mitral valve (MV) regurgitation (MR) is a highly prevalent heart disease that
requires surgery in severe cases. Here, we show that a decrease in the activity of the …

Rationale: Myocardial infarction (MI) causes a severe injury response that eventually leads
to adverse cardiac remodeling and heart failure. Lactoferrin (Ltf), as a secreted protein …