In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

As a result of research in the 1980s on in vitro maturation, sperm capacitation, and in vitro
fertilization, the bovine is now one of the important models for development. Further, the …

The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility
and fertilization via HCO3−-stimulated cAMP synthesis. A complex network of signaling …

Forty years ago, MC Chang found that exposing capacitated rabbit sperm to seminal plasma
made them incapable of fertilizing eggs in vivo [1]. The results of this rather unphysiological …

Mammalian spermatozoa expend energy, generated as intracellular ATP, largely on motility.
If the sperm cell cannot swim by use of its flagellar motion, it cannot fertilize the egg. Studies …

After leaving the testis, mammalian spermatozoa from many species are morphologically
differentiated but have acquired neither progressive motility nor the ability to fertilize a …

Capacitation is an important physiological pre-requisite before the sperm cell can acrosome
react and fertilize the oocyte. Recent reports from several laboratories have amply …

Here we show a unique example of male infertility conferred by a gene knockout of the
sperm-specific, pH-dependent SLO3 potassium channel. In striking contrast to wild-type …

The involvement of cAMP in the process of sperm capacitation has been the subject of
several studies. In addition, the importance of protein-tyrosine phosphorylation in this …

Fertilization is a matter of life or death. In animals of sexual reproduction, the appropriate
communication between mature and competent male and female gametes determines the …